Journal: Frontiers in Pharmacology
Article Title: Ponatinib alleviates non-alcoholic steatohepatitis through TFEB-mediated autophagy
doi: 10.3389/fphar.2024.1505768
Figure Lengend Snippet: Ponatinib reduced the liver fibrosis and injury induced by MCD. (A) The relative mRNA levels of genes associated to fibrosis were tested by qPCR. (B) Hepatic gene expression associated with inflammation was measured by qPCR in mice fed with MCS or MCD diet and treated with ponatinib or vehicle for 4 weeks. (C, D) The levels of liver function markers AST (C) and ALT (D) in the serum of mice. n = 5, Data represent mean ± SEM. * P < 0.05, *** P < 0.001 vs. MSD group. # P < 0.05, ## P < 0.01, ### P < 0.001vs. MCD group.
Article Snippet: The MCD diet and methionine and choline sufficient (MCS) diet were purchased from Research Diets Inc (Bergenfield, NJ, United States).
Techniques: Gene Expression